Scientists Discover Link Between TBI and PTSD

 


The first evidence of a connection between traumatic brain injury and an increased susceptibility to post-traumatic stress disorder has been published by U C L-A researchers in the journal Biological Psychology.  Following an examination of the amygdala and the behaviors of rats subjected to "fear conditioning", the researchers discovered that brain injury causes the amygdala to be in a more excitable state, preparing it for the acquisition of powerful fear. 


The first evidence of a causal link between an increased risk of post-traumatic stress disorder and traumatic brain injury has been provided by life scientists at the University of California, Los Angeles (U C L-A). 



M I-C HA-E L F-A N S E-L O W, a U C L-A professor of psychology and the senior author of the study, stated that the observed correlation between traumatic brain injury, or T B-I, and P T S D, particularly in military veterans returning from overseas service, was the motivation behind the study, which was conducted in rats


It is unknown why this correlation exists. It's possible that traumatic brain injury (T B-I) and post-traumatic stress disorder (P T S D) are unrelated, and that the events that result in brain injury are also extremely frightening. However, Fanselow and his coworkers speculated that the two "could be linked in a more mechanistic way". 


Utilizing methodology to isolate the physical and close-to-home injuries, the researchers prepared the rodents using "dread molding" procedures two days after they encountered a concussive cerebrum injury, guaranteeing the mind injury and the experience of dread happened on various days. 


F A-N S-E L O W, a member of the U C L-A Brain Research Institute, stated, We found that the rats with the earlier T B-I acquired more fear than the control rats (without T B-I). Because of the brain injury, they were more likely to develop an inappropriately strong fear. It appeared as though the injury had prepared the brain to learn to be afraid.


The amygdala, the brain's crucial hub for fear learning, was analyzed by the researchers to ascertain the reason for this.


M-A X I-N-E R E-G-E R, a U C L-A psychology graduate student and the study's lead author, stated, "We found that there are significantly more receptors for excitatory neurotransmitters that promote learning". He was working in Dr F-A N S E-K O W laboratory at U C L-A.


According to Fanselow, "this finding suggests that brain injury leaves the amygdala in a more excitable state that prepares it for acquiring powerful fear". 


The U C L-A Brain Injury Research Center, the US Department of Defense, and the National Institutes of Health all contributed funds to the study.


The research was conducted in conjunction with H O V D-A laboratory, which studies brain injury, and Fanselow's laboratory, which studies the neural mechanisms of anxiety disorders.


D-A V I-D, director of the U C L-A Brain Injury Research Center and professor of neurosurgery and molecular and medical pharmacology at the David Geffen School of Medicine at U C L-A, was one of the study's co-authors. Postdoctoral fellow in F-A N S E-L O W lab, Andrew P O U L O S; Floyd B U-E N, a former H O V D-A Laboratory graduate student; and Christopher Giza, an associate professor at the Geffen School of Medicine who specializes in neurosurgery


According to Fanselow, "the spirit of collaboration that allows scientists from very different departments to combine their very different expertise to answer important but difficult questions" is one of U C L-A the greatest strengths

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