Insomnia Is a Potential Risk Factor for Highly Fatal Brain Aneurysm Rupture

 


Aneurysm subarachnoid hemorrhage, a type of stroke, and brain aneurysm, also known as an intracranial aneurysm, were identified as potential risk factors for insomnia by researchers. 


A higher risk of brain aneurysm was also linked to smoking and high blood pressure, two known risk factors for stroke. 


The discovery that insomnia may be a risk factor for intracranial aneurysms is novel and requires additional research, according to the researchers. 


According to new research that was published today in the Journal of the American Heart Association, an open access journal of the American Heart Association, insomnia may be a potential risk factor for a brain bleed caused by a ruptured aneurysm, along with the more well-known risk factors of smoking and high blood pressure. 


In the brain, more than 3% of adults have intracranial aneurysms, which are unruptured blood vessel malformations that will never rupture. A subarachnoid hemorrhage (SAH), also known as a brain bleed, occurs when about 2.5% of intracranial aneurysms rupture. When a blood vessel on the surface of the brain ruptures and bleeds into the space between the brain and the skull, SAH is a type of stroke


Aneurysm rupture is extremely fatal. According to study author Susanna C. Larsson, PhD, associate professor in the unit of cardiovascular and nutritional epidemiology in Stockholm, Sweden, and the unit of medical epidemiology at Uppsala University in Uppsala, Sweden, "it is therefore extremely important to identify modifiable risk factors that can help prevent aneurysms from rupturing". 


The goal of the study was to see if there was a connection between an intracranial aneurysm and its rupture. They looked at the relationship between aneurysms and coffee consumption, sleep, physical activity, body mass index (BMI), blood glucose levels, type 2 diabetes, blood pressure, cholesterol, chronic inflammation, and kidney function, as well as established risk factors like smoking and high blood pressure. 


In order to evaluate the genetic connections between lifestyle and cardio metabolic risk factors, data from several genome-wide association studies was utilized. Nearly 6,300 cases of intracranial aneurysm and nearly 4,200 cases of aneurysm subarachnoid hemorrhage were identified using genetic data from a meta-analysis conducted by the International Stroke Genetics Consortium. Over 59,500 controls and cases of intracranial aneurysm and subarachnoid hemorrhage were compared to determine a genetic predisposition to aneurysms. The report concludes:


An increased risk of 24% for intracranial aneurysm subarachnoid hemorrhage was found to be linked to a genetic predisposition for insomnia. 


When compared to nonsmokers, smokers had about three times the risk of developing an intracranial aneurysm. 


For every 10 mm Hg increase in diastolic blood pressure—the lowest number on a blood pressure reading—the risk of developing an intracranial aneurysm was almost tripled. 


An increased risk of intracranial aneurysm subarachnoid hemorrhage was not demonstrated by high triglyceride levels or body mass index (BMI).


Insomnia and intracranial aneurysms have never been linked before, and these findings call for further investigation, according to Larsson. Brain aneurysm and hemorrhage risk may be affected by risk factors that people can change or manage, as supported by our research. Once confirmed, future research ought to investigate ways to incorporate this knowledge into therapies and prevention programs. 


A 2016 scientific statement from the American Heart Association, Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardio metabolic Health: A higher risk of high blood pressure is associated with insufficient and poor-quality sleep, as well as sleep disorders. The summary of the statement mentions that treating sleep disorders may have clinical benefits, especially for blood pressure

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