First 3D Interaction Images of Vitamin B12 During Methyltransfer

 


A newly published report documents the first full 3-D images of B12 interacting with other molecules during the reaction known as methyl transfer. This reaction is vital for human cells and bacteria cells that consume carbon dioxide and carbon monoxide


It is listed on the side of your cereal box and in the bottle of your multivitamin. It is vitamin B12, which, like the other vitamins and minerals, should be included in a healthy diet. 


However, new research suggests that B12 transforms into a gymnast once it enters the body. 


The first full 3-D images of B12 and its partner molecules twisting and contorting as part of a crucial reaction called methyl transfer have been created, according to researchers from the University of Michigan Health System and the Massachusetts Institute of Technology, according to a paper that was recently published in the journal Nature. 


In a slightly different way, the cells of bacteria that consume carbon dioxide and carbon monoxide are affected by this reaction, which is essential for both human cells and those of bacteria. This includes the bacteria that aid in digestion and live in cows, humans, and other animals' intestines. B12 complexes from a different kind of carbon dioxide-munching bacteria found in the murky bottoms of ponds were used in the new research


For the first time, the team's three-dimensional images demonstrate the complex molecular balancing required for B12 to perform its biologically necessary function. A surprisingly complicated mechanism for such a crucial reaction is revealed by their depiction of a multi-stage process involving what the researchers refer to as an "exquisite protein framework."

 

U-M Clinical School teacher and co-creator Stephen Rags dale noticed that this movement response is vital to comprehend because of its significance to human wellbeing. Additionally, it could have an impact on the creation of new fuels that could eventually replace traditional sources of renewable energy. 

 

"Heart disease and birth defects may be much more prevalent without this transfer of single carbon units involving B12 and its partner B9 (also known as folic acid)", Rags dale, a professor of biological chemistry, explains. In a similar vein, the bacteria that depend on this reaction would not be able to remove carbon dioxide or carbon monoxide from our bodies or the atmosphere, nor would they be able to eat it to stay alive. Therefore, it is crucial on numerous levels.

 

The reaction is part of a larger process called the Wood L J N N G D-A H L pathway in these bacteria, which are called anaerobes. It is what enables the organisms to survive on carbon dioxide, a greenhouse gas that is directly linked to climate change, and carbon monoxide, a gas that is harmful to other living things. Rags dale says that the industry is looking into using the Wood L J U N GD-A H L pathway to make chemicals and liquid fuels 


Rags dale is a faculty member at the University of Michigan Energy Institute in addition to his position at the Medical School. 


The scientists demonstrate in the images they produced how the complex of molecules twists into multiple conformations to first activate, then protect, and finally catalyze the B12 molecule. The complex had been isolated from the bacteria Morelia, which serves as a model for studying this kind of reaction. 


Focusing intense X-ray beams on crystallized forms of the protein complex and meticulously determining the position of each atom inside produced the images. 


According to the authors, "this paper provides an understanding of the remarkable conformational movements that occur during one of the key steps in this microbial process, the step that involves the generation of the first in a series of organ metallic intermediates that lead to the production of the key metabolic intermediate, acetyl-CoA". This step is one of the key steps in this microbial process

Comments

Post a Comment

Popular posts from this blog

What Is Difference Between Chia Seeds And Flaxseed

Image
  Certain seeds have gained a reputation as superfoods in recent years. Examples include the well-known chia and flax seeds. Both have been linked to health benefits such as a healthier heart, lower blood sugar levels, and protection against certain types of cancer. However, many people wonder which of the two seeds is actually the healthiest. Both are extremely rich in nutrients. To answer this question, this article looks at the scientific evidence that supports each The Saliva Hispanic plant, more commonly referred to as the chia plant, is the source of the tiny oval-shaped chia seeds. Chia seeds are slightly larger and flatter than flax seeds. Flax seeds, on the other hand, have a slightly nuttier flavor than chia seeds. However, incorporating both kinds of seeds into a variety of dishes is simple Nutrition comparison Comparative analysis of the nutrients present in chia and flax seeds The major nutrients contained in a 1-ounce (28-gram) serving, or approximately 4 tablespoons,...
Read more

Overconsumption of Common Red Food Dye May Lead to Inflammatory Bowel Disease

Image
  Allure Red AC, a synthetic dye found in popular foods like Skittles, Doritos, Gatorade, Jell-O, and Fruit Loops, has been linked to an increased risk of developing inflammatory bowel diseases (I-B D S) such as Crohn's disease and ulcerative colitis if consumed frequently. The dye, also known as FD & C Red 40 and Food Red 17, is thought to have negative effects on gut health and increase inflammation, according to a small study done on laboratory mice. The study, which was recently published in Nature Communications, found that the additive directly breaks the gut barrier, which helps keep bacteria from getting in, and that it also makes more serotonin, a hormone and neurotransmitter in the gut. According to the report, this reaction alters the microbiome of the gut, making people more likely to develop inflammatory bowel conditions. What we have found is striking and alarming, as this common synthetic food dye may be a dietary trigger for I-B D S, said senior author W-A L-I U...
Read more

Border violence displaces 76,000 in Lebanon: Hezbollah

 The International Organization for Migration (IOM) of the United Nations reported on Friday that nearly three months of nearly daily fighting along the border with Israel had resulted in the displacement of more than 76,000 people in Lebanon. The boundary region has seen a flood of viciousness since early October, with blow for blow trades of fire forging ahead with Friday between Israeli powers and Hezbollah. In a report distributed on Thursday, the IOM said that the heightening had uprooted 76,018 individuals, predominantly in areas of southern Lebanon lining Israel. More than 80% of the dislodged Lebanese are remaining with family members, as per the report, and just two percent housed in 14 aggregate sanctuaries spread across the south of the country, predominantly in the seaside city of Tire and in the Hasbaya locale. The remainder, according to the UN agency, have relocated to homes or apartments further from the border. Cross-line brutality has left 175 individuals dead in ...
Read more